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doi: 10.1016/j.bmc.2021.116466 [DOI] [PubMed] [Google Scholar] 62.Wang H, Shi W, Zeng D, et al

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5.3 Lung cancer and pancreatic cancer T-bet exhibits dual roles in lung cancer: it promotes lung adenocarcinoma progression by maintaining tumor stemness and activating the T-bet-IL-4 signaling pathway, while simultaneously being highly expressed in TAA-specific tumor-infiltrating Treg (TIL-Treg) within the tumor microenvironment, potentially contributing to antitumor immune responses