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Because glutathione is the major intracellular antioxidant defense within a cell, it is proposed that its depletion might be a prerequisite for modulating the apoptotic machinery in autoimmune disease like SLE (Figure 6)

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[ 2 H9]-trimethyllysine [TML] and [ 13 C6, 15 N2]-lysine labelling in cells Cells were seeded in 6-well plates and grown in DMEM supplemented with 10% FBS overnight