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Particularly noteworthy is that FOXO4 influences not only lifespan but also the quality of aging through its interaction with the protein p53—commonly referred to as the "guardian of the genome." This interaction regulates whether cells remain in a senescent, metabolically inactive state or undergo programmed cell death (apoptosis)
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fumigatus that contribute to the pathogenesis of IA have traditionally focused on single-gene deletion and mutant characterization
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