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Emerging Approaches in Glioblastoma Treatment: Modulating the Extracellular Matrix Through Nanotechnology - PMC

For instance, zinc deficiency—a condition known to generate oxidative stress—has been shown to reduce IL-6 promoter methylation in human lymphoblastoid cell line (THP-1 cells), which was associated with a marked increase in IL-6 expression compared with control cells [110]

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Knockout of ascorbate-specific biosynthetic enzymes prevents ascorbate synthesis and results in arrest of seedling growth after germination while Arabidopsis vtc mutants with ~20% wild-type ascorbate can grow