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These mechanisms indicate that the autoreactivity of the adaptive immune system drives PH vascular inflammation and remodeling through multi-dimensional pathways, including B cell-T cell axis imbalance, Treg functional exhaustion, abnormal antigen presentation, and virus-immune interactions (Figure 1)

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[DOI] [PMC free article] [PubMed] [Google Scholar] 87.Lee AP, Mulligan K, Schambelan M, Murphy EJ, Weiss EJ